关于我们

随着高通量测序技术的飞速发展,雪崩式的基因组学大数据正向我们奔袭而来,如何从这些海量数据中挖掘生物学知识,已成为生物信息学亟需解决的核心问题。课题组以高通量测序数据为基础,运用生物信息学和分子生物学技术,解密基因信息,识别基因组暗物质,并探索基因表达调控机制。

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研究方向

课题组利用二代和三代高通量测序技术,组装完整的动植物基因组,注释完整基因信息,绘制基因表达谱;识别基因组中非编码RNA,可翻译的非编码RNA,并探索这些基因组暗物质对基因表达调控的机理;整合多组学测序数据,构建生物信息学数据库,开发高通量测序数据处理流程及分析软件。

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组学技术

课题组使用二代和三代测序技术结合多组学分析技术解密基因组信息

基因组

从头拼接组装基因组,识别基因变异位点,全基因组关联分析

转录组

绘制基因表达谱,鉴定差异表达基因和选择性剪接事件

甲基化组

评估全基因组甲基化水平,鉴定差异甲基化区域

翻译组

了解蛋白质表达情况及丰度,识别可翻译的非编码RNA

最新成果

  • Lianming Du, Chaoyue Geng, Qianglin Zeng, Ting Huang, Jie Tang, Yiwen Chu, Kelei Zhao. Dockey: a modern integrated tool for large-scale molecular docking and virtual screening. Briefings in Bioinformatics, 2023, 24(2):bbad047.

  • Lianming Du, Qin Liu, Zhenxin Fan, Jie Tang, Xiuyue Zhang, Megan Price, Bisong Yue, Kelei Zhao. Pyfastx: a robust Python package for fast random access to sequences from plain and gzipped FASTA/Q files. Briefings in Bioinformatics, 2021, 22(4):bbaa368.

  • Lianming Du, Qin Liu, Kelei Zhao, Jie Tang, Xiuyue Zhang, Bisong Yue, Zhenxin Fan. PSMD: An extensive database for pan-species microsatellite investigation and marker development. Molecular Ecology Resources, 2020, 20(1):283-291.

  • Lianming Du, Tao Guo, Qin Liu, Jing Li, Xiuyue Zhang, Jinchuan Xing, Bisong Yue, Jing Li, Zhenxin Fan. MACSNVdb: a high-quality SNV database for interspecies genetic divergence investigation among macaques. Database, 2020, 2020:baaa027.

  • Kelei Zhao, Ting Huang, Jiafu Lin, Chaochao Yan, Lianming Du, Tao Song, Jing Li, Yidong Guo, Yiwen Chu, Junfeng Deng, Xinrong Wang, Chaolan Liu, Yingshun Zhou. Genetic and Functional Diversity of Pseudomonas aeruginosa in Patients With Chronic Obstructive Pulmonary Disease. Frontiers in Microbiology, 2020, 11:598478.

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