With the rapid development of high-throughput sequencing technology, the avalanche of genomic data is coming towards us. How to mine biological knowledge from these massive data has become a pressing problem in bioinformatics. Meanwhile, the boom of sequencing technology has led to emergence of various omics technologies, such as transcriptome, exome, methylome, metagenome, translatome, proteome, metabolome, etc. These technologies allow us to discover gene mutation, expression regulation and translation modification at different levels.

Based on high-throughput sequencing data, our research group employed bioinformatics, genomics, and molecular biology techniques to assemble complete genomes, accurately annotate gene information, reveal genomic dark matters, and further investigate the impact of these dark matters (non-coding RNAs, translatable non-coding RNAs) on regulation of gene expression. Additionally, our research group constructs bioinformatics database by integrating multiple omics datasets and establishing complex network between these datasets. Our group also develops efficient tools to process biological data.